General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 rCRTH2 β-Arrestin Cell Line, 2 vials. (93-0580C2)
The PathHunter rCRTH2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of rCRTH2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rCRTH2 and EA-tagged β-Arrestin-2. Activation of rCRTH2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC HuNS1; Myeloma; Human (Homo sapiens)
HuNS1 is a lymphoblast-like cell from a male with myeloma. This line was derived from the GM4672 cell line (Human Genetic Mutant Cell Repository, Coriell Institute for Medical Research) following ethylmethanesulfonate (EMS) treatment. The cell can be used in immune system disorders and immunology research.
Eurofins Discoverx PathHunter HEK 293 IFNAR1/IFNAR2 Dimerization Cell Line, 2 vials. (93-1097C1)
The PathHunter IFNAR1/IFNAR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IFN-beta) induced dimerization of IFNAR1/IFNAR2 receptors. This product uses EFC technology. The cell line included overexpresses IFNAR2 target protein fused to PK alongside IFNAR1 target protein fused to EA. Upon ligand-induced dimerization of IFNAR1/IFNAR2, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Eurofins Discoverx PathHunter CHO-K1 CCRL1 β-Arrestin Cell Line, 2 vials. (93-0946C2)
The PathHunter CCRL1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL19/MIP-3β) based activation of CCRL1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCRL1 and EA-tagged β-Arrestin-2. Activation of CCRL1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Panc 02.03; Pancreas Adenocarcinoma; Human (Homo sapiens)
Panc 02.03 is a (Cell type) cell line that was isolated in 1995 from the pancreas of a White, 70-year-old, female patient with adenocarcinoma. This cell line was deposited by EM Jaffee and can be used in cancer research.
Biochain Institute Inc Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Jejunum, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PathHunter CHO-K1 GPR79 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0408C2A)
The PathHunter GPR79 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR79 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR79 and EA-tagged β-Arrestin-2. Activation of GPR79 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Genscript Corporation CHO-K1/VISTA Stable Cell Line
Recombinant CHO-K1 cells stably overexpress V-domain Ig suppressor of T cell activation (VISTA) on the cell surface The surface expression of VISTA is validated by FACS analysis This cell line is designed for cell-based binding for screening antibodies binding with VISTA and evaluating target binding affinity
Eurofins Discoverx ChemiScreen V1A Vasopression Receptor Stable Cell Line, 2 vials. (HTS059C)
The ChemiScreen V1A Vasopressin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. vasopressin) based activation of AVPR1A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR1A alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR1A, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Biochain Institute Inc Colon Tumor Tissue Array - 64 Different Colon tumors. Plus positive control and negative control, 2 slides/PK
BioChain's tissue arrays or tissue microarrays (TMAs) are a useful tool in biomarker research and drug target validation. It consists of paraffin blocks that are assembled in array fashion to allow multiplex histological analysis. BioChain's TMAs provide a valuable tool for analysis of protein, RNA, or DNA molecules in oncology, both the malignant and metastatic markers. TMAs can also be constructed with tissues from other diseases and species.
Biochain Institute Inc Paraffin Tissue Section - Human Angioma: Glomus Tumor, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC Transmissible; gastroenteritis virus; Strain: Purdue (attenuated)
Transmissible gastroenteritis virus strain Purdue (attenuated) is propagated in ST cells (ATCC CRL-1746). This strain was originally isolated from the small intestine of an infected pig with mild diarrhea and was deposited under the catalog number ATCC VR-763. It was then passaged through a 0.2 μM cellulose acetate membrane syringe filter and re-assigned to the catalog number ATCC VR-1995. This viral strain can be used in viral neutralization tests, agricultural research, and infectious and enteric disease research.
Abcam Bradykinin, Bradykinin receptor agonist, 25MG
MW 1120.3 Da, Purity >95%. Bradykinin, Bradykinin receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx ChemiScreen GPR54/KiSS1 Receptor Stable Cell Line, 2 vials. (HTS032C)
The ChemiScreen GPR54/KiSS1 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of KISS1R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses KISS1R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of KISS1R, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CCR10 Chemokine Receptor Stable Cell Line, 2 vials. (HTS014C)
The ChemiScreen CCR10 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL27) based activation of CCR10 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR10 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR10, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.